Tuning coordination chemistry through the second sphere in designed metallocoiled coils.
Louise N SlopeMichael G HillCatherine F SmithPaul TeareFelicity J de CoganMelanie M BrittonAnna F A PeacockPublished in: Chemical communications (Cambridge, England) (2020)
The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applied to lanthanide coiled coils.