Current data illustrates that the combined use of HL2/3 cells and the simulated BBB presents an accurate, physiologically relevant in vitro model with which to study neuroinflammation in the context of HIV/AIDS. In addition, our results caution against the use of S.frutescens as anti-inflammatory modality at any stage post-HIV infection.
Keyphrases
- hiv aids
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- hiv positive
- traumatic brain injury
- anti inflammatory
- induced apoptosis
- lipopolysaccharide induced
- lps induced
- cognitive impairment
- cell cycle arrest
- blood brain barrier
- electronic health record
- cerebral ischemia
- inflammatory response
- high resolution
- hepatitis c virus
- big data
- oxidative stress
- machine learning