SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease.
Valeria ContiGraziamaria CorbiValentina ManzoPaola MalangoneCarolina VitaleAngelantonio MaglioRoberta CotugnoDamiano CapaccioLuigi MarinoCarmine SelleriCristiana StellatoFilippelli AmeliaAlessandro VatrellaPublished in: Oxidative medicine and cellular longevity (2018)
These findings suggest loss of SIRT1-driven antioxidant activity as relevant in COPD pathogenesis and identify SIRT1 activity as a potential convenient biomarker for identification of mild/moderate, stable COPD.