Atypical femur fracture incidence in women increases with duration of bisphosphonate exposure.

Joan C LoC D GrimsrudS M OttM ChandraR L HuiB Ettinger

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2019)

Incidence of AFF increases markedly after 4-6 years of BP. These trends align with southern California and confirm a strong BP duration-related risk of this rare but serious event.

Keyphrases

risk factors
polycystic ovary syndrome
type diabetes
metabolic syndrome
adipose tissue
insulin resistance
drug induced