Design And Statistical Optimization Of Novel Polyelectrolyte Complex Microbeads To Improve Entrapment Efficiency And Release Study Of Vildagliptin.

The result suggested the combination of two polymers (Sodium alginate and Eudragit RL100) were suitable for improving the entrapment efficiency of hydrophilic drug (Vildagliptin). The central composite design (CCD) technique is an effective tool for obtaining optimal drug delivery systems of Vildagliptin polyelectrolyte complex microbeads.