Pharmacokinetics and pharmacodynamics of high-dose isoniazid for the treatment of rifampicin- or multidrug-resistant tuberculosis in Indonesia.
Vycke YunivitaFajri GafarPrayudi SantosoLidya ChaidirArto Y SoerotoTriana N MeirinaLindsey Te BrakeDick MenziesRob E AarnoutseRovina RuslamiPublished in: The Journal of antimicrobial chemotherapy (2024)
Isoniazid exposures below targets were observed in most patients, and certain risk groups for low isoniazid exposures may require dose adjustment. The effect of low isoniazid exposures on delayed culture conversion deserves attention.
Keyphrases
- mycobacterium tuberculosis
- high dose
- air pollution
- multidrug resistant
- pulmonary tuberculosis
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- low dose
- peritoneal dialysis
- prognostic factors
- working memory
- gram negative
- stem cell transplantation
- cystic fibrosis
- klebsiella pneumoniae
- hiv aids
- human immunodeficiency virus
- antiretroviral therapy