4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.

Yun-Dong YouWen-Hong DengWen-Yi GuoLiang ZhaoFang-Chao MeiYu-Pu HongYu ZhouJia YuSheng XuWei Xing Wang

Published in: Digestive diseases and sciences (2019)

ERS may be considered a predominant pathway, which is involved in the apoptosis of IECs during SAP. Furthermore, 4-PBA protects IECs against apoptosis in STC-induced SAP by attenuating the severity of ERS.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
drug induced
cell proliferation
diabetic rats
oxidative stress
cell death
signaling pathway