Primary sclerosing cholangitis with IgG4-positive plasma cells in bile duct biopsies - Frequency and characterization.

Taotao ZhouFlorian FronhoffsGlen KristiansenLeona DoldDominik J KaczmarekChristian P StrassburgTobias J Weismüller

Published in: Journal of digestive diseases (2024)

IgG4+ PC ≥10/HPF can be found abundantly in bile duct biopsies in PSC. Histological findings correlated with serum IgG4, age, and high-grade bile duct strictures. IgG4+ PC was located multifocally, hinting at a systemic biliary phenotype.

Keyphrases

high grade
induced apoptosis
cell cycle arrest
ultrasound guided
cell proliferation
signaling pathway
cell death
drug induced