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A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death.

Francesca RosatoRajeev PasupuletiJana TomischAna Valeria MeléndezDajana KolanovicOlga N MakshakovaBirgit WiltschiWinfried Römer
Published in: Journal of translational medicine (2022)
This research highlights the potential of lectins in targeting certain tumors, with an opportunity for new cancer treatments. When considering a combinatorial strategy, lectin-based platforms of this type offer the possibility to target glycan epitopes on tumor cells and boost the efficacy of current therapies, providing an additional strategy for tumor eradication and improving patient outcomes.
Keyphrases
  • papillary thyroid
  • cell death
  • squamous cell
  • lymph node metastasis
  • squamous cell carcinoma
  • helicobacter pylori infection
  • cell proliferation
  • helicobacter pylori