A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl-3 H]quinuclidinyl benzilate methiodide.

Published in: Journal of labelled compounds & radiopharmaceuticals (2020)

A useful synthesis of (R)-[N-methyl-3 H]quinuclidinyl benzilate methiodide is described with the product characterized by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), tritium nuclear magnetic resonance (NMR), and mass spectrometry (MS). Several methods are provided to purify the radioligand, and its storage and stability are also discussed.

Keyphrases

high performance liquid chromatography
mass spectrometry
magnetic resonance
liquid chromatography
tandem mass spectrometry
high resolution
simultaneous determination
solid phase extraction
ms ms
gas chromatography
capillary electrophoresis
contrast enhanced
multiple sclerosis
high speed