GPC3-IL7-CCL19-CAR-T primes immune microenvironment reconstitution for hepatocellular carcinoma therapy.

Li-Li LuShu-Xiu XiaoZhi-Yuan LinJin-Jin BaiWei LiZheng-Qing SongYu-Hong ZhouBin LuWei-Zhong Wu

Published in: Cell biology and toxicology (2023)

HCCs. ►Compared with conventional GPC3-CAR-T, GPC3-7-CCL19-CAR-T cells could reverse tumor immunosuppressive microenvironment by reducing PMN-MDSC and Treg cell infiltration.

Keyphrases

stem cells
liver fibrosis
liver injury
cell therapy
drug induced
bone marrow
smoking cessation
replacement therapy