Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2.

Long ZhangLihe ChenChao GaoEnuo ChenAndrea R LightleLlewellyn FoulkeBihong ZhaoPaul J HigginsWenzheng Zhang

Published in: Journal of the American Society of Nephrology : JASN (2019)

Our study confirms Dot1l to be a genetic and epigenetic modifier of kidney fibrosis, reveals a new mechanism regulating Edn1 transcription by Dot1a and HDAC2, and reinforces endothelin 1 as a therapeutic target of kidney fibrosis.

Keyphrases

histone deacetylase
dna methylation
gene expression
genome wide
liver fibrosis
transcription factor
copy number