The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer's disease.

Giulia AbateGiovanni B FrisoniJean-Christophe BourdonSimona PiccirellaMaurizio MemoDaniela Letizia Uberti

Published in: Alzheimer's research & therapy (2020)

These findings revisit the role of p53 in the early development and exacerbation of AD pathology, both in the brain and periphery. The conformational variant of p53 represents a potential peripheral biomarker that could detect AD at its earliest stages.

Keyphrases

chronic obstructive pulmonary disease
resting state
molecular dynamics
spinal cord
molecular dynamics simulations
white matter
cognitive decline
single molecule
functional connectivity
multiple sclerosis
spinal cord injury
brain injury
subarachnoid hemorrhage
blood brain barrier