Gene expression profiling of mouse cavernous endothelial cells for diagnostic targets in diabetes-induced erectile dysfunction.

Guo Nan Yin JiYeon Ock Min-Ji Choi Limanjaya Anita Kalyan Ghatak Kang-Moon Song Mi Hye Kwon Jun Kyu Suh Ji Kan Ryu

Published in: Investigative and clinical urology (2020)

Our gene expression profiling studies showed that Cyp1a1, Gclm, Igfbp5, Nqo1, Il6, Cxcl5, Olr1, Ctgf, Hbegf, Serpine1, Cyr61, Angptl4, and Loxl2 may play a critical role in diabetes-induced ED through aging and angiogenesis signaling. Additional research is necessary to help us understand the potential mechanisms by which these genes influence diabetes-induced ED.

Keyphrases

gene expression
high glucose
endothelial cells
type diabetes
cardiovascular disease
emergency department
diabetic rats
dna methylation
glycemic control
oxidative stress
transcription factor
climate change
risk assessment
human health
bioinformatics analysis