Survival benefit of lymphadenectomy for gallbladder cancer based on the therapeutic index: An analysis of the US extrahepatic biliary malignancy consortium.
Kota SaharaDiamantis I TsilimigrasShishir K MaithelDaniel E AbbottGeorge A PoultsidesIoannis HatzarasRyan C FieldsMatthew J WeissCharles ScogginsChelsea A IsomKamran IdreesPerry ShenItaru EndoTimothy M Pawliknull nullPublished in: Journal of surgical oncology (2020)
Certain clinicopathological factors including T1 or T4 tumor and CA19-9 ≥200 UI/mL were associated with a low therapeutic index. Resection of six or more LNs was associated with a meaningful therapeutic index benefit among patients with LNM.