Overall and patient-specific comparative effectiveness of dimethyl fumarate versus teriflunomide: A novel approach to precision medicine applied to the German NeuroTrans Data Multiple Sclerosis Registry.

Xiaotong JiangGabrielle SimoneauMel ZuercherYanic HeerPhilip van HoevellAdrian HarringtonWanda Castro-BorreroCarl de MoorFabio PellegriniLu TianArnfin BergmannStefan Braune

Published in: Multiple sclerosis journal - experimental, translational and clinical (2023)

The implemented approach can disentangle prognostic differences from treatment effect heterogeneity and provide unbiased patient-specific profiling of comparative effectiveness based on real-world data.

Keyphrases

multiple sclerosis
electronic health record
single cell
big data
white matter
combination therapy
deep learning