The effect of dexamethasone on uterine receptivity, mediated by the ERK1/2-mTOR pathway, and the implantation window: An experimental study.

Behrooz NiknafsNaser ShokrzadehMohammad Reza AlivandMohammad Bakhtiar Hesam Shariati

Published in: International journal of reproductive biomedicine (2022)

It appears that dexamethasone can diminish uterine receptivity during the implantation period, at least to some extent, through the alteration of particular genes that impact endometrial receptivity. Furthermore, the mTOR pathway seemingly showed an essential role in endometrial receptivity.

Keyphrases

cell proliferation
low dose
high dose
endometrial cancer
signaling pathway
genome wide
pi k akt
dna methylation