Recent Progress on Relevant microRNAs in Autism Spectrum Disorders.
Xingwang WuWanran LiYun ZhengPublished in: International journal of molecular sciences (2020)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.
Keyphrases
- autism spectrum disorder
- attention deficit hyperactivity disorder
- intellectual disability
- end stage renal disease
- gene expression
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- transcription factor
- oxidative stress
- binding protein
- copy number
- subarachnoid hemorrhage
- congenital heart disease
- cerebral ischemia
- heat stress