Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer.

Mateo Sokač Johanne AhrenfeldtKevin LitchfieldThomas B K WatkinsMichael Knudsen Lars Dyrskjøt Martin Roelsgaard Jakobsen Nicolai Juul Birkbak

Published in: Cancer research communications (2022)

The cGAS-STING pathway is induced by CIN, triggers inflammation and is often deficient in cancer. We provide a tool to evaluate cGAS-STING activity and demonstrate clinical significance in immunotherapy response.

Keyphrases

squamous cell carcinoma
oxidative stress
small cell lung cancer
papillary thyroid
gene expression
copy number
young adults