The regulatory role of APE1 in epithelial-to-mesenchymal transition and in determining EGFR-TKI responsiveness in non-small-cell lung cancer.

Xiao YangYu PengXuan JiangXianfeng LuWei DuanShiheng ZhangNan DaiJinlu ShanYan FengXuemei LiYi ChengYuxin YangLaura BaughGianluca TellDong WangMeng-Xia Li

Published in: Cancer medicine (2018)

This study revealed a significant role of APE1 in EGFR-TKI resistance via novel regulatory effects on the EMT phenotype in NSCLC.

Keyphrases

tyrosine kinase
small cell lung cancer
epidermal growth factor receptor
advanced non small cell lung cancer
transcription factor
epithelial mesenchymal transition
single cell