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Policosanol protects against Alzheimer's disease-associated spatial cognitive decline in male rats: possible involved mechanisms.

Samaneh SafariNaser MiraziNesa AhmadiMasoumeh AsadbegiAlireza NourianMasome RashnoAlireza Komaki
Published in: Psychopharmacology (2023)
The results suggest that amelioration of hippocampal synaptic plasticity impairment, modulation of oxidant/antioxidant status, and inhibition of Aβ plaque formation by PCO may be the mechanisms behind its protective effect against AD-associated spatial cognitive decline.
Keyphrases
  • cognitive decline
  • mild cognitive impairment
  • anti inflammatory
  • oxidative stress
  • coronary artery disease
  • temporal lobe epilepsy