Use of Biologics to Treat Relapsing and/or Refractory Eosinophilic Granulomatosis With Polyangiitis: Data From a European Collaborative Study.
Alice CanzianNils VenhoffMaria Letizia UrbanSilvia SartorelliAnne-Marie RuppertMatthieu GrohNicolas GirszynCamille TailléFrançois MaurierVincent CottinClaire de MoreuilVincent GermainMaxime SamsonMarie JachietLaure DenisVirginie RieuPerrine SmetsGrégory PugnetAlban DerouxCécile-Audrey DurelAchille AoubaPascal CathébrasChristophe DelignyStanislas FaguerHelder GilBertrand GodeauFrançois LifermannSophie Phin-HuynhMarc RuivardPhilippe BonniaudXavier PuechalJean-Emmanuel KahnJens ThielLorenzo DagnaLoïc GuillevinAugusto VaglioGiacomo EmmiBenjamin Terriernull nullPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
These results suggest that RTX could be effective in treating relapses of EGPA vasculitis. MEPO is highly effective with a good safety profile in patients with GC-dependent asthma. Our data suggest that 100 mg MEPO monthly could be an acceptable dosage for first-line therapy in selected instances of EGPA, recognizing, however, that this has not been compared to the validated dosage of 300 mg monthly.