The interplay between microbiota-dependent metabolite trimethylamine N-oxide, Transforming growth factor β/SMAD signaling and inflammasome activation in chronic kidney disease patients: A new mechanistic perspective.

Omnia Safwat El-Deeb Marwa Mohamed Atef Yasser Mostafa Hafez

Published in: Journal of cellular biochemistry (2019)

The study documented that TMAO could be used as a reliable biomarker to evaluate CKD progression; being linked to TGF-β/SMAD signaling, NLRP3 inflammasome activation as well as being a noninvasive applicable technique.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
nlrp inflammasome
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
signaling pathway