Transcriptomic biomarker pathways associated with death in HIV-infected patients with cryptococcal meningitis.

Irina Vlasova-St LouisAbdu K MusubireDavid B MeyaHenry W NabetaHesham MoheiDavid R BoulwarePaul R Bohjanen

Published in: BMC medical genomics (2021)

Our results showed that overactivated innate immunity, involving Toll-like receptor/inflammasome pathways, and inflammation-induced oxidative stress, are associated with fatal outcomes. The results of this study provide insight into the molecular drivers of death and fatal C-IRIS to inform future diagnostic test development or guide targeted treatments.

Keyphrases

toll like receptor
hiv infected patients
nuclear factor
inflammatory response
antiretroviral therapy
immune response
oxidative stress
hydrogen peroxide
single cell
cerebrospinal fluid
rna seq
nitric oxide
insulin resistance
glycemic control