Pirfenidone prevents acute kidney injury in the rat.

Ixchel Lima-PosadaFrancesco FontanaRosalba Pérez-VillalvaNathan Berman-ParksNorma A Bobadilla

Published in: BMC nephrology (2019)

This study shows that prophylactic administration of pirfenidone prevented acute kidney injury due to bilateral ischemia in the rat. Recovery of NO production appears to be one of the mechanism of pirfenidone renoprotective effect. Our findings suggest that pirfenidone is a promising drug to reduce renal injury induced by I/R.

Keyphrases

idiopathic pulmonary fibrosis
pulmonary fibrosis
acute kidney injury
oxidative stress
cardiac surgery
mouse model
adverse drug