Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway.
Rahul KhatriSybille MazurekSebastian Friedrich PetryThomas LinnPublished in: Stem cell research & therapy (2020)
The infusion of hTERT-MSC after partial pancreatectomy (Px) through the IVR and IPR facilitated the proliferation of autochthonous pancreatic β-cells and provided evidence for a regenerative influence of MSC on the endocrine pancreas. Moderate benefit of IPR over IVR was observed which could be a new treatment option for preventing diabetes mellitus after pancreas surgery.
Keyphrases
- mesenchymal stem cells
- signaling pathway
- stem cells
- cell therapy
- induced apoptosis
- umbilical cord
- minimally invasive
- cell cycle arrest
- pi k akt
- single cell
- cell proliferation
- transcription factor
- bone marrow
- low dose
- high intensity
- type diabetes
- surgical site infection
- combination therapy
- atrial fibrillation
- skeletal muscle
- replacement therapy