Dihydropyrimidinase-like 2 can serve as a novel therapeutic target and prognostic biomarker in acute myeloid leukemia.

Fenglin LiQing LingJiaying LianYing ChenChao HuMin YangXiang ZhangChenying LiShihui MaoWenle YeXia LiXiangjie LinWenwen WeiXin HuangJiajia PanYu QianJinghan Wang Ying Lu Jie Jin

Published in: Cancer medicine (2023)

We first time confirmed that DPYSL2 was a target of HHT and played an oncogene role in AML by regulating JAK/STAT signaling pathway. Therefore, DPYSL2 could serve as a novel prognostic marker and therapeutic target for AML treatment.

Keyphrases

acute myeloid leukemia
signaling pathway
allogeneic hematopoietic stem cell transplantation
pi k akt
epithelial mesenchymal transition
cell proliferation