A 65-year-old man was referred to our hospital to undergo orthopedic surgery due to severe cervical ossification of the posterior longitudinal ligament. Computed tomography scanning showed a massive osteolytic lesion in his pelvis. Other screening examinations including detection of bone mineral density and osteoporosis biomarkers, bone scintigram and 18F-fluorodeoxyglucose-positron emission tomography were all normal. Bone marrow aspiration revealed slightly increased plasmacytes at 3.8%. These findings led to a diagnosis of monoclonal gammopathy with undetermined significance (MGUS). Architectural osteolytic bone associated with MGUS without apparent abnormality in bone mineral metabolism could be a common occurrence prior to onset or occurrence of multiple myeloma.
Keyphrases
- bone mineral density
- positron emission tomography
- computed tomography
- postmenopausal women
- body composition
- multiple myeloma
- bone marrow
- magnetic resonance imaging
- risk assessment
- pet ct
- healthcare
- minimally invasive
- mesenchymal stem cells
- emergency department
- soft tissue
- bone regeneration
- coronary artery bypass
- contrast enhanced
- single cell
- coronary artery disease
- atrial fibrillation
- percutaneous coronary intervention
- high resolution
- bone loss
- quantum dots
- electron microscopy