Transcriptional landscape of PTEN loss in primary prostate cancer.
Eddie Luidy ImadaDiego Fernando SanchezWikum DinalankaraThiago VidottoEricka M EbotSvitlana TyekuchevaGloria Regina FrancoLorelei Ann MucciMassimo LodaEdward Matthew SchaefferTamara LotanLuigi MarchionniPublished in: BMC cancer (2021)
We created a PCa specific signature of the transcriptional landscape of PTEN loss that comprises both the coding and an extensive non-coding counterpart, highlighting potential new players in PCa progression. We also show that contrary to what is observed in other cancers, PTEN loss in PCa leads to increased activation of the immune system. These findings can help the development of new biomarkers and help guide therapy choices.