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Signaling interactions predicted by the Tritope model of the TCR.

Melvin Cohn
Published in: Immunologic research (2018)
As the data accumulates, it becomes obvious that the Standard Model of TCR structure-function relationships is in jeopardy. The proposed Tritope model has become more meaningful and, in any case, is richer in prediction and explanation. This is illustrated here by using the signaling interactions of the TCR as examples. An unsuspected signaling pathway for positive selection, and for alloreactivity, is predicted. Further, crucial data needed to elucidate the structural elements that distinguish signaling for restrictive- versus allo-reactivity are identified.
Keyphrases
  • regulatory t cells
  • signaling pathway
  • electronic health record
  • big data
  • immune response
  • epithelial mesenchymal transition
  • oxidative stress
  • dendritic cells
  • deep learning