Genomic and proteomic characterization of Philadelphia-like B-lineage acute lymphoblastic leukemia: A report of Indian patients.
Dikshat Gopal GuptaNeelam VarmaAshish KumarShano NaseemMan Updesh Singh SachdevaSreejesh SreedharanunniJogeshwar BinotaParveen BoseAlka KhadwalPankaj MalhotraSubhash VarmaPublished in: Cancer (2023)
In developing countries, detecting Philadelphia (Ph)-like B-lineage acute lymphoblastic leukemia is complicated and challenging due to its diverse genetic landscape. There is no well-defined and cost-effective methodology for its detection. The incidence of this high-risk subtype is very high in adult cases, and there is an urgent need for its accurate detection. We have developed an online PHi-RACE classifier for its rapid detection, followed by delineating the genomic and proteomic landscape of Ph-like acute lymphoblastic leukemias for the first time in Indian patients.
Keyphrases
- acute lymphoblastic leukemia
- end stage renal disease
- ejection fraction
- loop mediated isothermal amplification
- label free
- chronic kidney disease
- single cell
- allogeneic hematopoietic stem cell transplantation
- prognostic factors
- peritoneal dialysis
- risk factors
- liver failure
- high resolution
- patient reported outcomes
- dna methylation
- drug induced
- hepatitis b virus
- acute respiratory distress syndrome