Microglia: Active participants in brain capillary function.
Connor DufortYangfan WangXiaoming HuPublished in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2022)
A recent study by Bisht, Okojie, and Sharma, et al. characterizes a population of capillary-associated microglia (CAM) whose cell bodies are positioned along small blood vessels in the healthy mouse brain. Through elegant, longitudinal intravital imaging of brain vasculature and CAMs, the authors have uncovered the significance of microglia in cerebral blood flow regulation. Further investigation into the functions of this CAM population and how they interact with surrounding cells within the neurovascular unit will improve our understanding of vascular regulation and cerebrovascular diseases.
Keyphrases
- cerebral blood flow
- inflammatory response
- neuropathic pain
- resting state
- white matter
- induced apoptosis
- high resolution
- single cell
- functional connectivity
- cell cycle arrest
- cerebral ischemia
- cell therapy
- multiple sclerosis
- endoplasmic reticulum stress
- cell death
- mass spectrometry
- signaling pathway
- mesenchymal stem cells
- pi k akt