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Nonenzymatic Self-Assembly Access to Diverse ortho -Quinone Methide-Based Pseudonatural Products.

Guangwei WuXuan QianYeqiang HuangYujia LiuLuning ZhouWei WangJing LiTianjiao ZhuQianqun GuDe-Hai Li
Published in: Organic letters (2022)
A nonenzymatic self-assembly program was introduced to explore diverse clavatol-based pseudonatural products (PNPs) in a marine-derived fungus. Intermolecular couplings of the chemoreactive ortho -quinone methide of clavatol with native acceptors led to 14 clavatol-based PNPs with five categories, and compounds 1 , 2 , 5 - 10 , and 12 are new. In particular, 1 and 2 possessed an unprecedented oxa-angular tetracyclic scaffold with highly oxidized modification and exhibited cytotoxicity. Such a program is proven to be of great advantage in constructing bioactive PNPs.
Keyphrases
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