Imaging biomarkers of behavioral impairments: A pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model.
R Maarten van DijkValentina Di LibertoMatthias BrendelAnn Marie WaldronChristina MöllerFranz Josef GildehausBarbara von Ungern-SternbergMagdalena LindnerSibylle ZieglerRainer HellwegPeter GassPeter BartensteinHeidrun PotschkaPublished in: Epilepsia (2018)
In the electrically induced post-status epilepticus rat model, we demonstrated hippocampal hypometabolism and its correlation with a range of neurobehavioral alterations. These findings require further confirmation in other preclinical models and patients with epilepsy and psychiatric disorders to address the value of [18 F]FDG uptake as an imaging biomarker candidate for psychiatric comorbidities in patients as well as for severity assessment in rodent epilepsy models.
Keyphrases
- high resolution
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- mental health
- peritoneal dialysis
- prognostic factors
- high glucose
- computed tomography
- stem cells
- mesenchymal stem cells
- temporal lobe epilepsy
- patient reported outcomes
- drug induced
- fluorescence imaging
- study protocol
- cell therapy
- brain injury