The association and functional relevance of genetic variation in low-to-medium-affinity Fc-gamma receptors with clinical platelet transfusion refractoriness.
Sietse Q NagelkerkeLeendert PorcelijnJudy GeisslerMichael W T TanckElly HuiskesRobin van BruggenTimo K van den BergMasja de HaasTaco W KuijpersPublished in: Journal of thrombosis and haemostasis : JTH (2020)
None of the tested FcγR genetic variations seemed associated with the development of severe PLT refractoriness. In contrast to observations in immune thrombocytopenia, genetic variation in FcγRs does not seem to influence the chance to develop PLT refractoriness. Our results do not support determination of FcγR genetic background as a means to identify patients most at risk for PLT refractoriness.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- genome wide
- chronic kidney disease
- magnetic resonance
- peritoneal dialysis
- cardiac surgery
- prognostic factors
- copy number
- early onset
- magnetic resonance imaging
- dna methylation
- acute kidney injury
- drug induced
- contrast enhanced
- solid phase extraction
- capillary electrophoresis