Extended Genotyping to Stratify the Risk of CIN2+ in Women with Persistent HPV Infection, Negative Cytology and Type 3 Transformation Zone.
Maria Teresa BrunoGaetano ValentiAntonino Giovanni CavallaroIlenia PalermoTiziana AielloJessica FarinaMarco Marzio PanellaLiliana MereuPublished in: Cancers (2024)
Women with viral persistence, negative cytology, and TZ3 have a 19% risk of CIN2+; genotyping helps stratify risk, but extensive genotyping is necessary instead of partial genotyping (16/18), referring to a population of women over 50 years old in which the prevalence of genotypes 16,18 decreases and the prevalence of other genotypes increases; diagnostic LEEP is excessive (only 16 cases of CIN2+ out of 48 cases treated), even though 83% of women had viral clearance after LEEP; p16/Ki67 double staining could be a potential risk marker, which would only highlight women at risk of CIN2+ to undergo LEEP. To individualize the diagnostic workup and treatment and minimize the risk of under diagnosis and overtreatment, future studies should explore the use of extended genotyping and new biomarkers for individual risk stratification.
Keyphrases
- genome wide
- high throughput
- polycystic ovary syndrome
- cervical cancer screening
- high grade
- genetic diversity
- breast cancer risk
- pregnancy outcomes
- risk factors
- sars cov
- fine needle aspiration
- dna methylation
- ultrasound guided
- physical activity
- skeletal muscle
- pregnant women
- weight gain
- current status
- radiation therapy
- weight loss
- lymph node
- smoking cessation
- case control
- high density