Xuanfei Baidu decoction ameliorates bleomycin-elicited idiopathic pulmonary fibrosis in mice by regulating the lung-gut crosstalk via IFNγ/STAT1/STAT3 axis.

Mengjie JiaYiman LiuJia LiuJunyu MengJiazhen CaoLin MiaoHan ZhangYan ZhuMengmeng SunJian Yang

Published in: Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)

Altogether, our results revealed that XFBD improved the BLM-elicited IPF mice by regulating gut-lung crosstalk via IFN-γ/STAT1/STAT3 axis and provided a new insight of gut-lung crosstalk in IPF, especially the dynamic changes of microorganisms in the damaged lungs needed to pay more attention during IPF therapy.

Keyphrases

idiopathic pulmonary fibrosis
cell proliferation
interstitial lung disease
immune response
dendritic cells
high fat diet induced
working memory
single cell
stem cells
adipose tissue
metabolic syndrome
skeletal muscle
wild type
cell therapy