Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.

Adi GrossFelix BenningerRavit MadarTomer IllouzKathleen GriffioenIsrael SteinerDaniel OffenEitan Okun

Published in: Epilepsia (2017)

This study reveals novel insights into the pathophysiology of epilepsy and the contribution of TLR3 to disease progression. Our results identify the TLR3 pathway as a potential future therapeutic target in SE.

Keyphrases

toll like receptor
inflammatory response
nuclear factor
immune response
temporal lobe epilepsy
high glucose
diabetic rats
current status
high fat diet induced
type diabetes
metabolic syndrome
oxidative stress
adipose tissue
drug induced
human health
endothelial cells