A Distinct Phylogenetic Cluster of Indian Severe Acute Respiratory Syndrome Coronavirus 2 Isolates.

Sofia BanuBani JollyPayel MukherjeePriya SinghShagufta KhanLamuk ZaveriSakshi ShambhaviNamami GaurShashikala ReddyK KaveriSivasubramanian SrinivasanDhinakar Raj GopalArchana Bharadwaj SivaKumarasamy ThangarajKarthik Bharadwaj TallapakaRakesh K MishraVinod ScariaDivya Tej Sowpati

Published in: Open forum infectious diseases (2020)

The cluster is characterized by a core set of 4 genetic variants and has a nucleotide substitution rate of 1.1 × 10-3 variants per site per year, which is lower than the prevalent A2a cluster. Epidemiological assessments suggest that the common ancestor emerged at the end of January 2020 and possibly resulted in an outbreak followed by countrywide spread. To the best of our knowledge, this is the first comprehensive study characterizing this cluster of SARS-CoV-2 in India.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
copy number
gene expression