Using a pharmacogenetic clinical decision support system to improve psychopharmacotherapy dosing in patients with affective disorders.

Michael ZastrozhinValentin Yurievich SkryabinAlexander SorokinOleg BuzikInessa BedinaElena GrishinaKristina RyzhikovaValery ShipitsynEvgeny BryunDmitry Sychev

Published in: Drug metabolism and personalized therapy (2020)

Pharmacogenetic-guided personalization of the drug dose in patients with affective disorders and comorbid alcohol use disorder can reduce the risk of undesirable side effects and pharmacoresistance. It allows recommending the use of pharmacogenetic CDSSs for optimizing drug dosage.

Keyphrases

clinical decision support
alcohol use disorder
bipolar disorder
electronic health record
adverse drug
drug induced
emergency department