An Active Learning Framework Improves Tumor Variant Interpretation.
Alexandra M BleeBian LiTurner PecenJens MeilerZachary D NagelAnthony CapraWalter Jacob ChazinPublished in: Cancer research (2022)
A novel machine learning approach predicts the impact of tumor mutations on cellular phenotypes, overcomes limited training data, minimizes costly functional validation, and advances efforts to implement cancer precision medicine.