Loss of progesterone receptor is associated with distinct tyrosine kinase profiles in breast cancer.
Andliena TahiriXavier TekpliSomisetty V SatheeshRik DeWijnTorben LüdersIda R BukholmAntoni HurtadoJürgen GeislerVessela N KristensenPublished in: Breast cancer research and treatment (2020)
Our results suggest that the PR status has a profound effect on tyrosine kinases, especially for FGFR4 and LCK genes, in ER+/HER2- breast cancer patients. The influence of these genes on the PI3K/AKT signaling pathway may potentially lead to novel drug targets for ER+/PR- breast cancer patients.
Keyphrases
- tyrosine kinase
- estrogen receptor
- signaling pathway
- epidermal growth factor receptor
- genome wide
- genome wide identification
- breast cancer cells
- pi k akt
- intellectual disability
- epithelial mesenchymal transition
- emergency department
- autism spectrum disorder
- transcription factor
- adverse drug
- drug induced
- cell proliferation
- childhood cancer