The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension.

Réka CsákiChandran NagarajJános AlmássyMohammad Ali KhozeimehDusan JeremicHorst OlschewskiAlice DobolyiKonrad HoetzeneckerAndrea OlschewskiPéter EnyediMiklós Lengyel

Published in: British journal of pharmacology (2024)

homeostasis of hPASMC, and therefore, essential for maintenance of a low resting pulmonary vascular tone. Thus TREK-1 may represent a new therapeutic target for PAH.

Keyphrases

pulmonary hypertension
pulmonary artery
pulmonary arterial hypertension
heart rate
heart rate variability
polycyclic aromatic hydrocarbons
human health
coronary artery