Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge Lamellodysidea herbacea.

Masumi ToriiHikaru KatoYuki HitoraEsther D AngkouwRemy E P MangindaanNicole J de VoogdSachiko Tsukamoto

Published in: Journal of natural products (2017)

Four new sesquiterpenes, lamellodysidines A and B, O,O-dimethyllingshuiolide A, and 11-epi-O,O-dimethyllingshuiolide A (1-4), were obtained from the marine sponge, Lamellodysidea herbacea, collected in Indonesia. Their planar structures were elucidated by analysis of spectroscopic data. The absolute configurations of the new compounds were determined by the calculated ECD spectra. Compound 1 has a unique carbon framework, and 2 is a new nitrogenous sesquiterpene.

Keyphrases

molecular docking
electronic health record
high resolution
big data
density functional theory
machine learning
deep learning
molecular dynamics