HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07).
Lue Ping ZhaoGeorge K PapadopoulosJay S SkylerAlberto PuglieseHemang M ParikhWilliam W KwokTerry P LybrandGeorge P BondinasAntonis K MoustakasRuihan WangChul-Woo PyoWyatt C NelsonDaniel E GeraghtyLernmark ÅkePublished in: Diabetes care (2024)
These results suggest that HLAII polymorphisms influence progression from islet autoimmunity to T1D among at-risk subjects with islet autoantibodies.