Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons.

Shanshan WuJing WangZicheng ZhangXinchen JinYang XuYouwen SiYixiao LiangYueping GeHuidong ZhanLi PengWenkai BiDandan LuoMengzhu LiBo MengQingbo GuanJiajun ZhaoLing GaoZhao He

Published in: Molecular autism (2024)

These results demonstrate that the Shank3 deficiency caused autistic-like behaviors by activating p38α signaling in AgRP neurons, suggesting that p38α signaling in AgRP neurons is a potential therapeutic target for Shank3 mutant-related autism.

Keyphrases

spinal cord
signaling pathway
intellectual disability
spinal cord injury
human health
wild type