The bi-directional effect of markers of inflammation and a decrease in glomerular filtration rate in chronic kidney disease.

The aim of the study was to analyze and evaluate the relationship between the cytokine profile, C-reactive blood protein, fibrinogen, and glomerular filtration rate in patients with chronic kidney disease. The study involved individuals (n = 816) with chronic kidney disease (CKD) from the 1st to 5th stage of the disease, aged 20 to 76 years. The male to female ratio was 48% and 52%, respectively. All examined individuals underwent a comprehensive clinical and laboratory study evaluating the concentration of interleukins (IL, IL-10, IL-6, TNF-α) and acute phase inflammation proteins (C-reactive protein, fibrinogen) in the blood. CKD categories were evaluated by glomerular filtration rate (GFR), which was calculated using the CKD-EPI formula (Chronic Kidney Disease Epidemiology Collaboration). In individuals with CKD, significantly high concentrations of IL-10 and IL-6 were observed at stage 3b of the disease. Systolic blood pressure, median TNF-α, blood fibrinogen, and the number of individuals with high CRP were significant at stage 4 of CKD. A statistically significant correlation was found between the estimated GFR with the level of IL-6, CRP, blood fibrinogen at the 2nd stage of the disease and the concentration of IL-10 at 3b and TNF-α at the 4th stage of CKD. At the initial stage of CKD, there is a significant relationship between a decrease in estimated GFR and an increase in the level of IL-6, IL-10, TNF-α, as well as an increase in CRP and blood fibrinogen, which becomes pronounced at stages 3b and 4 of CKD.