Maternal high-fat diet programs white and brown adipose tissue lipidome and transcriptome in offspring in a sex- and tissue-dependent manner in mice.

Christina SavvaLuisa Alejandra HelgueroMarcela González-GranilloTânia MeloDaniela CoutoByambajav BuyandelgerSonja GustafssonJianping LiuMaria Rosário DominguesXidan LiMarion Korach-André

Published in: International journal of obesity (2005) (2022)

Maternal HFD modulates metabolic profile in offspring in a sex-dependent manner. A sex- and maternal diet-dependent gene programming exists in VAT, SAT, and BAT which may be key player in the sexual dimorphism in the metabolic adaptation later in life.

Keyphrases

high fat diet
adipose tissue
insulin resistance
birth weight
pregnancy outcomes
genome wide
high fat diet induced
gene expression
public health
gestational age
weight loss
physical activity
metabolic syndrome
single cell
type diabetes
transcription factor
body mass index
wild type