Brain metabolites in cholinergic and glutamatergic pathways are altered by pancreatic cancer cachexia.

Paul T WinnardSantosh Kumar BhartiRaj Kumar SharmaBalaji KrishnamacharyYelena MironchikMarie-France PenetMichael G GogginsAnirban MaitraIhab KamelKaren M HortonMichael A JacobsZaver M Bhujwalla

Published in: Journal of cachexia, sarcopenia and muscle (2020)

Disturbances in metabolites of the choline/cholinergic and glutamine/glutamate/glutamatergic neurotransmitter pathways may contribute to morbidity. Metabolic normalization may provide strategies to reduce morbidity. The human plasma metabolite changes observed may lead to the development of companion diagnostic markers to detect PDAC and PDAC-induced cachexia.

Keyphrases

ms ms
high glucose
diabetic rats
resting state
white matter
drug induced
endothelial cells
functional connectivity
cerebral ischemia
stress induced