ADRB3 polymorphism rs4994 (Trp64Arg) associates significantly with bodyweight elevation and dyslipidaemias in Saudis but not rs1801253 (Arg389Gly) polymorphism in ARDB1.

Maha DaghestaniMazin DaghestaniMamoon DaghistaniAbdelmoneim EldaliZeinab K HassanMaha H ElaminArjumand Sultan Warsy

Published in: Lipids in health and disease (2018)

The results of this study have shown a significant association between the Trp64Arg polymorphism in ADRB3 gene and the development of overweight and obesity in Saudi populations. It also has an influence on the levels of lipid, insulin, leptin, and glucose, whereas, Arg389Gly polymorphism in ADRB1 is not associated with overweight, obesity or dyslipidaemias in Saudis.

Keyphrases

type diabetes
weight loss
metabolic syndrome
insulin resistance
physical activity
gene expression
dna methylation
copy number
blood pressure
skeletal muscle
high fat diet induced
transcription factor
saudi arabia